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Which Blood Groups Can You Safely Mix?

In this activity, you will learn what blood groups can be safely mixed together.

Materials needed:
  • 5 cups with water
  • eye droppers
  • red & blue food coloring

EXPERIMENT

Step 1: Fill four cups about 1/2 full with water and label them as follows: Group A, Group B, Group AB and Group O
Step 2: Leave the fifth cup empty and label it Patient.
Step 3: Add some red food coloring to cup A, blue food coloring to B, and equal amounts of red and blue food coloring to cup AB.
Step 4: Do not put any food coloring in cup O.
Step 5:
Pour a small amount of liquid from one of the four groups into the cup marked "Patient." The patient now has that group of blood and needs a transfusion. To perform the transfusion, use a medicine dropper to transfer "blood" from any of the four groups to the patient cup. As long as the liquid in the patient cup does not change color, the transfusion is safe. If a color change does occur, record the mixing as unsafe. Then, rinse out the patient cup before running the next test.

EXAMPLE

  1. Pour Group A liquid into the patient cup.
  2. If you add Group O liquid to a Group A patient, no color change occurs. It remains red. Therefore, a Group A individual can safely receive Group O blood.
  3. However, if you add Group B liquid to the Group A patient, the color changes from red to blue-red or purple and is not safe.
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